[Red-cell immune functions, T subsets and B-cell detection and their clinical significances in patients with primary lung cancer].

Abstract

BACKGROUND:

To explore the relation between red-cell immune status and distribution of T subsets and B-cell and their clinical significances in patients with primary lung cancer .

METHODS:

The red-cell immune functions and distribution of T subsets and B-cell in the peripheral blood were detected in 60 patients with primary lung cancer and 40 normal adults as control by Guo-Feng's methods and indirect immunofluorescence technique respectively. The detection of red-cell immune funtions included the rossett rate of red-cell immune adherence activity of C3b receptors ( RBC-C3bRR) and that of red-cell immune complex ( RBC-ICR) and that of direct erythrocyte-cancer cell immune adherence ( RBC-CaR) .

RESULTS:

The RBC-C3bRR and RBC-CaR in the patients with primary lung cancer were significantly lower than those in the controls ( P < 0. 01) , and the CD3+ and CD4+ and CD20+ scores and CD4+ / CD8+ ratio were significantly lower in the patients than those in the controls ( P < 0. 01 or 0. 05) , but the RBC-ICR in the patients was also significantly higher than that in the controls ( P < 0. 01) , and the CD8+ score in the patients was not remarkably changed than that in the controls ( P > 0. 05) . The direct correlation between the CD4+ score and the RBC-C3bRR was observed in the patients ( r= 0. 811 2, P < 0. 01) , but there was no remarkable correlation among the other subjects ( P > 0. 05) .

CONCLUSIONS:

There are abnormalities of T subsets and B-cell and red-cell immune functions in patients with primary lung cancer. There may be a direct interaction between T helper cell and C3b receptors on erythrocytes, which may play an important role in immunity regulation in patients with primary lung cancer.

• Authors: H Wan, X Zeng, J Yu, M Wen, S Cheng
• Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer (Zhongguo Fei Ai Za Zhi) Vol. 4 Issue 5 Pg. 351-3 (Oct 20 2001) ISSN: 1009-3419 [Print] China
• PMID: 21059315 (Publication Type: English Abstract, Journal Article)