Abstract | OBJECTIVE: PATIENTS AND METHODS: • Between January 2008 and April 2009, 19 patients with recurrent UTIs presented VUR proven by voiding cystourethrography. • To correct VUR of the transplanted ureter, DHAC was injected endoscopically using hydrodistention technique. • Pre- and postoperative serum creatinine levels, the number of pre- and postoperative UTIs, postoperative complications and reflux resolution rate were recorded. The mean follow-up was 6.5 months. RESULTS: • The average number of UTIs was reduced significantly from 4.89 (range 2-14) to 1.31 (range 0-4) on pre- and postoperative follow-up, respectively, of 6 months (P < 0.001). The success rate increased from 57.9% after the first injection to 78.9% after the second injection. • The remaining four patients with residual VUR received long-term low dose antibiotic prophylaxis. In total, two (10.5%) patients developed increasing creatinine levels postoperatively as a result of distal ureteral obstruction, and temporary urinary drainage was necessary in both patients. CONCLUSIONS: • DHAC appears to be an efficient and minimal invasive method for treating VUR after renal transplantation with respect to short-term success. • Further investigation with a larger group of patients and longer follow-up is needed to evaluate the prolonged effect, as well as any potential side effects.
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Authors | Renate Pichler, Alexander Buttazzoni, Peter Rehder, Georg Bartsch, Hannes Steiner, Josef Oswald |
Journal | BJU international
(BJU Int)
Vol. 107
Issue 12
Pg. 1967-72
(Jun 2011)
ISSN: 1464-410X [Electronic] England |
PMID | 21059169
(Publication Type: Evaluation Study, Journal Article)
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Copyright | © 2010 THE AUTHORS. BJU INTERNATIONAL © 2010 BJU INTERNATIONAL. |
Chemical References |
- Biocompatible Materials
- Dextrans
- dextranomer-hyaluronic acid copolymer
- Hyaluronic Acid
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Topics |
- Adult
- Aged
- Biocompatible Materials
(administration & dosage)
- Dextrans
(administration & dosage)
- Female
- Humans
- Hyaluronic Acid
(administration & dosage)
- Kidney Transplantation
(adverse effects)
- Male
- Middle Aged
- Retrospective Studies
- Secondary Prevention
- Treatment Outcome
- Ureteroscopy
- Urinary Tract Infections
(etiology, prevention & control)
- Vesico-Ureteral Reflux
(etiology, therapy)
- Young Adult
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