Galectin-1 attenuates astrogliosis-associated injuries and improves recovery of rats following focal cerebral ischemia.
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| Abstract |
Astrogliosis occurs after brain ischemia, and excessive astrogliosis can devastate the neuronal recovery. Previous reports show that galectin-1 (Gal-1) regulates proliferation of several cell types and plays an important role after nervous system injuries. Here, we found that expression of Gal-1 was remarkably up-regulated in activated astrocytes around ischemic infarct. Furthermore, under ischemic conditions either in vitro or in vivo, Gal-1 was found to inhibit the proliferation of astrocytes in a dose-dependent manner, attenuate astrogliosis and down-regulate the astrogliosis associated expression of nitric oxide synthase and interleukin-1β after the ischemia. All these changes were blocked by lactose, suggesting a lectin dependent manner of Gal-1's function. Moreover, 7-day Gal-1 treatment reduced apoptosis of neurons, decreased brain infarction volume and improved neurological function induced by the ischemia. Together, these findings indicate that through reducing astrogliosis related damages, Gal-1 is a potential therapeutical target for attenuating neuronal damage and promoting recovery of brain ischemia.
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| Authors | Wen-Sheng Qu, Yi-Hui Wang, Jun-Fang Ma, Dai-Shi Tian, Qiang Zhang, Deng-Ji Pan, Zhi-Yuan Yu, Min-Jie Xie, Jian-Ping Wang, Wei Wang |
| Journal | Journal of neurochemistry (J Neurochem) Vol. 116 Issue 2 Pg. 217-26 (Jan 2011) ISSN: 1471-4159 [Electronic] England |
| PMID | 21054390 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | © 2010 The Authors. Journal of Neurochemistry © 2010 International Society for Neurochemistry. |
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