Abstract | BACKGROUND: MATERIAL AND METHODS: We replaced extended-release OXC by ESL abruptly according to a 1:1 ratio in 12 patients. Standardized tests and questionnaires addressing side effects, quality of life and alertness were performed immediately prior and 5 days after the switch. We also measured the serum levels of sodium and the common metabolite monohydroxy derivative. RESULTS: No problems occurred. Concerning the parameters investigated no significant differences were found. In 9 of 12 cases serum sodium levels fell without clinical consequences. CONCLUSION: The exchange of extended-release OXC by ESL is easy to perform. Clinically relevant alterations were not apparent immediately after the switch. Sodium serum level controls are recommended also with the use of ESL.
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Authors | B J Steinhoff, E Trinka, A S Wendling |
Journal | Der Nervenarzt
(Nervenarzt)
Vol. 82
Issue 6
Pg. 764-7
(Jun 2011)
ISSN: 1433-0407 [Electronic] Germany |
Vernacular Title | Abrupter Austausch von retardiertem Oxcarbazepin gegen Eslicarbazepinacetat. |
PMID | 21052972
(Publication Type: Journal Article)
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Chemical References |
- Anticonvulsants
- Delayed-Action Preparations
- Dibenzazepines
- Carbamazepine
- eslicarbazepine acetate
- Oxcarbazepine
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Topics |
- Adult
- Anticonvulsants
(administration & dosage)
- Carbamazepine
(administration & dosage, analogs & derivatives)
- Delayed-Action Preparations
- Dibenzazepines
(administration & dosage)
- Drug Therapy, Combination
- Epilepsy
(drug therapy)
- Female
- Humans
- Male
- Middle Aged
- Oxcarbazepine
- Treatment Outcome
- Young Adult
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