Abstract | OBJECTIVE: METHODS: The human MC1R gene is highly polymorphic; therefore, we sequenced the entire MC1R coding region of 1122 bp in 181 depressed Mexican-American patients and 185 Mexican-American controls. RESULTS: A total of 23 single nucleotide polymorphisms (SNPs, 15 known and eight new) were found within the sequenced region. Among the common SNPs, the nonsynonymous SNP, rs885479 (R163Q) was associated with the diagnosis of depression (P=0.04). The nonsynonymous SNP, rs2228479 (V92M) and the synonymous SNP, rs2228478 were found to be associated with the remission with desipramine treatment. No associations were found for remission with fluoxetine treatment or for the combined sample treated with fluoxetine or desipramine. The frequency of one (H2) of the five haplotypes identified was higher in depressed patients when compared with controls (P=0.05). In-silico functional analysis indicates that SNPs rs885479 and rs2228479 have significant impact on the protein function. CONCLUSION:
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Authors | Gui-Sheng Wu, Huai-Rong Luo, Chuanhui Dong, Claudio Mastronardi, Julio Licinio, Ma-Li Wong |
Journal | Psychiatric genetics
(Psychiatr Genet)
Vol. 21
Issue 1
Pg. 14-8
(Feb 2011)
ISSN: 1473-5873 [Electronic] England |
PMID | 21052032
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antidepressive Agents
- Receptor, Melanocortin, Type 1
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Topics |
- Antidepressive Agents
(pharmacology, therapeutic use)
- Base Sequence
- Depression
(drug therapy, genetics)
- Female
- Gene Frequency
(genetics)
- Genetic Association Studies
- Genetic Predisposition to Disease
- Haplotypes
(genetics)
- Humans
- Male
- Mexican Americans
(genetics)
- Molecular Sequence Data
- Mutation
(genetics)
- Polymorphism, Single Nucleotide
(genetics)
- Receptor, Melanocortin, Type 1
(genetics)
- Remission Induction
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