| Abstract |
We synthesized diyne triols based on gymnasterkoreayne and evaluated their cancer chemopreventive activities in terms of the chemopreventive index (CI) to reveal the structure-activity relationship, and discovered more active compounds than natural diynes. |
| Authors | Dongyun Shin, Jung-Eun Yang, Saet Byoul Lee, Chu Won Nho |
| Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 20
Issue 24
Pg. 7549-52
(Dec 15 2010)
ISSN: 1464-3405 [Electronic] England |
| PMID | 21050753
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Copyright | Copyright © 2010. Published by Elsevier Ltd. |
| Chemical References |
- Anticarcinogenic Agents
- Enediynes
- gymnasterkoreaside B
- gymnasterkoreayne G
- Acetylene
|
| Topics |
- Acetylene
(analogs & derivatives, chemical synthesis, chemistry, therapeutic use)
- Anticarcinogenic Agents
(chemical synthesis, chemistry, therapeutic use)
- Enediynes
(chemical synthesis, chemistry, therapeutic use)
- Humans
- Structure-Activity Relationship
|
