Clear cell basal cell carcinoma with pulmonary metastasis: case report and literature review.

Abstract

Clear cell basal cell carcinoma is a rare histological variant of basal cell carcinoma, which has been well described in the literature. We herein report a case of a 56-year-old man who developed lung metastasis from a rather aggressive tumor that grew very rapidly to involve the parotid gland, the mandibular bone, and even the petrous portion of the temporal bone, the middle ear, and the dura mater. Histological diagnosis was clear cell carcinoma, and initially a salivary origin was suspected. Only in the resection specimen, we found areas of more conventional basal cell carcinoma, and final diagnosis was clear cell basal cell carcinoma. We herein report a case of this rare variant and comment on the histopathological differential diagnosis and the possible relation between these tumors and Gorlin-Goltz syndrome.

• Authors: M J Fernández-Aceñero, Carlos Cenjor, Sharon Córdova
• Journal: The American Journal of dermatopathology (Am J Dermatopathol) Vol. 33 Issue 4 Pg. 379-82 (Jun 2011) ISSN: 1533-0311 [Electronic] United States
• PMID: 21048492 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Biomarkers, Tumor

Topics

• Adenocarcinoma (metabolism, secondary, surgery)
• Adenocarcinoma, Clear Cell (metabolism, secondary, surgery)
• Biomarkers, Tumor (metabolism)
• Carcinoma, Squamous Cell (diagnosis)
• Diagnosis, Differential
• Focal Dermal Hypoplasia (pathology)
• Humans
• Lung Neoplasms (metabolism, secondary, surgery)
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Parotid Neoplasms (diagnosis)
• Skin Neoplasms (metabolism, pathology, surgery)