Importance of controlling drug-resistant Pseudomonas aeruginosa infection: experience from lung transplantation in a cystic fibrosis case.

Abstract

Cystic fibrosis (CF) is rare in Japan. We encountered a CF case with drug-resistant Pseudomonas aeruginosa infection and successfully performed lung transplant from living related donors. A combination of beta-lactams and aminoglycosides for drug-resistant P. aeruginosa infection was administered before lung transplantation. Intravenous colistin was also used immediately before and after transplant surgery. Gram staining of respiratory specimens was performed every day after surgery and it was useful in monitoring infection status. Strict monitoring of infections by the Gram staining and culture of respiratory specimens is considered to be effective in preventing lower respiratory infection in lung transplantation.

• Authors: Yoshihiro Yamamoto, Koichi Izumikawa, Atsuko Hara, Hanako Fujita, Misato Amenomori, Noriho Sakamoto, Masafumi Seki, Hiroshi Kakeya, Katsunori Yanagihara, Kenji Takasaki, Takuro Miyazaki, Tomoshi Tsuchiya, Naoya Yamasaki, Tsutomu Tagawa, Takeshi Nagayasu, Shigeru Kohno
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 49 Issue 21 Pg. 2353-8 ( 2010) ISSN: 1349-7235 [Electronic] Japan
• PMID: 21048374 (Publication Type: Case Reports, Journal Article)

Chemical References

• Aminoglycosides
• beta-Lactams

Topics

• Aminoglycosides (therapeutic use)
• Cystic Fibrosis (complications, diagnosis, drug therapy)
• Drug Resistance, Bacterial
• Humans
• Lung Transplantation (adverse effects)
• Male
• Pseudomonas Infections (diagnosis, drug therapy, etiology)
• Pseudomonas aeruginosa (isolation & purification)
• Young Adult
• beta-Lactam Resistance
• beta-Lactams (therapeutic use)