[Intravitreal ranibizumab injections for the treatment of choroidal neovascularization complicating high myopia].

Abstract

INTRODUCTION:

Macular choroidal neovascularization (CNV) is a serious complication of high myopia, compromising the visual prognosis in young patients. The purpose of this study was to evaluate the safety and efficacy of first-line intravitreal ranibizumab in the treatment of myopic CNV.

PATIENTS AND METHODS:

We conducted a single-center prospective, consecutive, interventional study of patients with subfoveal or juxtafoveal CNV secondary to pathologic myopia (PM) treated with intravitreal injection of ranibizumab in the Beni-Messous University Hospital from January 2009 to April 2010. Best-corrected visual acuity (BCVA), fundus examination, optical coherence tomography (OCT), and fluorescein angiography (FA) were performed at baseline and monthly for all patients. Indications for retreatment were persistence or recurrence of the neovascular activity.

RESULTS:

The study included 40 eyes of 40 patients, 33 of whom were females (82.5%), with a mean age of 40.22 ± 10.81 years (range, 20-55 years), with visual acuity between 1/100 and 1/10. The mean spherical equivalent refractive error was -14.13 ± 4.65 diopters (range, -7 D to -23 D). The mean follow-up time was 8 months (range, 3-15 months). The mean number of intravitreal injections administered for each patient was 2.2 (range: 1-4). Follow-up ranged from 3 to 15 months (mean, 8 months). All patients maintained or improved their vision; the average gain in visual acuity was three lines (range: 1-9 lines). No injection complications or drug-related side effects were noted during the follow-up period.

DISCUSSION:

Intravitreal ranibizumab to treat CNV complicated by high myopia seems to be associated with an improvement in VA and good tolerance. This study confirms the efficacy of first-line anti-VEGF, in particular, ranibizumab in this indication.

CONCLUSION:

In this series of eyes with limited follow-up, intravitreal ranibizumab was a safe and effective treatment for CNV secondary to PM, resulting in functional and anatomic improvement.

• Authors: O Ouhadj, A Bouarfa, S Akel, L Mendil, A Nebab, M T Nouri
• Journal: Journal francais d'ophtalmologie (J Fr Ophtalmol) Vol. 33 Issue 9 Pg. 649-54 (Nov 2010) ISSN: 1773-0597 [Electronic] France
• Vernacular Title: Néovaisseaux choroïdiens du myope fort: traitement par injection intravitréenne de ranibizumab.
• PMID: 21047702 (Publication Type: Clinical Trial, English Abstract, Journal Article)
• Copyright: Copyright © 2010 Elsevier Masson SAS. All rights reserved.

Chemical References

• Antibodies, Monoclonal
• Antibodies, Monoclonal, Humanized
• Ranibizumab

Topics

• Adult
• Antibodies, Monoclonal (administration & dosage)
• Antibodies, Monoclonal, Humanized
• Choroidal Neovascularization (drug therapy, etiology)
• Female
• Humans
• Intravitreal Injections
• Male
• Middle Aged
• Myopia (complications)
• Prospective Studies
• Ranibizumab
• Young Adult