Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony.

Abstract

OBJECTIVE:

We sought to determine if women with severe postpartum hemorrhage (PPH) secondary to uterine atony received greater amounts of oxytocin during labor compared to women without PPH.

STUDY DESIGN:

Subjects with severe PPH secondary to uterine atony, who received a blood transfusion, were compared to matched controls. Total oxytocin exposure was calculated as the area under the concentration curve (mU/min*min). Variables were compared using paired t test, χ², and logistic regression.

RESULTS:

Women with severe PPH had a mean oxytocin area under the curve of 10,054 mU compared to 3762 mU in controls (P < .001). After controlling for race, body mass index, admission hematocrit, induction status, magnesium therapy, and chorioamnionitis using logistic regression, oxytocin area under the curve continued to predict severe PPH.

CONCLUSION:

Women with severe PPH secondary to uterine atony were exposed to significantly more oxytocin during labor compared to matched controls.

• Authors: Chad A Grotegut, Michael J Paglia, Lauren N C Johnson, Betty Thames, Andra H James
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 204 Issue 1 Pg. 56.e1-6 (Jan 2011) ISSN: 1097-6868 [Electronic] United States
• PMID: 21047614 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2011 Mosby, Inc. All rights reserved.

Chemical References

• Oxytocics
• Oxytocin

Topics

• Adult
• Area Under Curve
• Blood Transfusion
• Body Mass Index
• Case-Control Studies
• Female
• Hematocrit
• Humans
• Logistic Models
• Oxytocics (administration & dosage, adverse effects)
• Oxytocin (administration & dosage, adverse effects)
• Postpartum Hemorrhage (ethnology, etiology)
• Pregnancy
• Uterine Inertia (ethnology)