Abstract | PURPOSE:
Biliary atresia (BA) is one of the most serious liver disorders in children. The aims of the present study were to investigate circulating levels of osteopontin in BA children compared with healthy controls and to evaluate the relationship between circulating osteopontin and therapeutic outcome of BA patients. METHODS: Fifty-nine BA patients post-Kasai operation and 13 healthy children were recruited. The patients were divided into two groups according to their serum total bilirubin levels (TB < 2, jaundice-free vs. TB ≥ 2 mg/dL, persistent jaundice) and alanine aminotransferase (ALT < 45, normal ALT vs. ALT ≥ 45 IU/L, elevated ALT). Plasma osteopontin levels were analyzed using commercial enzyme-linked immunosorbent assay. RESULTS: The circulating osteopontin was higher in BA children compared with that of healthy controls (146.9 ± 19.1 vs. 28.0 ± 8.4 ng/mL, P = 0.001). The BA patients with persistent jaundice had more increased plasma osteopontin levels than those without jaundice (157.8 ± 47.9 vs. 27.5 ± 6.4 ng/mL, P = 0.001). Furthermore, plasma osteopontin levels in BA patients with elevated ALT were significantly higher than those with normal ALT (103.2 ± 29.2 vs. 24.5 ± 7.9 ng/mL, P = 0.01). In addition, circulating osteopontin was positively correlated with serum total bilirubin (r = 0.526, P < 0.001) and with serum ALT (r = 0.575, P < 0.001). Subsequent analysis showed that the BA patients with portal hypertension had more elevated plasma osteopontin compared to those without portal hypertension (116.7 ± 31.1 vs. 19.5 ± 9.3 ng/mL, P = 0.01). CONCLUSION:
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Authors | Sittisak Honsawek, Paisarn Vejchapipat, Voranush Chongsrisawat, Nutchanart Thawornsuk, Yong Poovorawan |
Journal | Pediatric surgery international
(Pediatr Surg Int)
Vol. 27
Issue 3
Pg. 283-8
(Mar 2011)
ISSN: 1437-9813 [Electronic] Germany |
PMID | 21046114
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Osteopontin
- Alanine Transaminase
- Bilirubin
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Topics |
- Alanine Transaminase
(blood)
- Area Under Curve
- Biliary Atresia
(blood, surgery)
- Bilirubin
(blood)
- Case-Control Studies
- Child
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Male
- Osteopontin
(blood)
- Postoperative Period
- ROC Curve
- Treatment Outcome
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