HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Involvement of gicerin, a cell adhesion molecule, in the portal metastasis of rat colorectal adenocarcinoma cells.

Abstract
Gicerin, an Ig-superfamily cell adhesion molecule, has homophilic adhesion activity, thus leading to the formation of gicerin aggregates. Gicerin is highly expressed in various embryonic tissues, and it contributes to development through its adhesive activities. In contrast, the expression of the protein is limited to the muscular tissues and endothelial cells in the mature animals. In the liver, gicerin is constitutively expressed in sinusoidal endothelial cells. Interestingly, an overexpression of gicerin is found in a variety of tumors and may play a role in tumorigenesis. Previously, up-regulated expression of the gicerin protein was found in some sporadic cases of chicken colorectal adenocarcinomas and their hepatic metastasized lesions. In the present study, gicerin cDNA was introduced into endogenous gicerin negative ACL-15 cells, a rat colon adenocarcinoma cell line. The cells were subsequently evaluated for changes in their metastatic potentials in order to elucidate the possible role of gicerin in the hepatic metastasis of colorectal adenocarcinomas. The stable overexpression of gicerin in the cells enhanced the self-aggregation and migratory activities on the protein compared with the mock-transfectants. In addition, the gicerin- transfectants had enhanced metastatic potential to the liver compared with mock-transfected cells after implantation into the ileocolic vein of the cognate rats. These results suggest that gicerin might promote the interaction of tumor cells with a hepatic endothelium, thus leading to the hepatic metastasis of colon adenocarcinomas.
AuthorsKazuhide Adachi, Mahiro Hattori, Hidenori Kato, Marie Inai, Masaya Tsukamoto, Ekowati Handharyani, Eiichi Taira, Yasuhiro Tsukamoto
JournalOncology reports (Oncol Rep) Vol. 24 Issue 6 Pg. 1427-31 (Dec 2010) ISSN: 1791-2431 [Electronic] Greece
PMID21042736 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CD146 Antigen
  • Cell Adhesion Molecules
Topics
  • Adenocarcinoma (genetics, metabolism, pathology)
  • Animals
  • CD146 Antigen (genetics, metabolism, physiology)
  • Cell Adhesion Molecules (genetics, metabolism, physiology)
  • Cell Aggregation (genetics)
  • Cell Line, Tumor
  • Cell Movement (genetics)
  • Colorectal Neoplasms (genetics, metabolism, pathology)
  • Liver Neoplasms (genetics, metabolism, secondary)
  • Male
  • Neoplasm Transplantation
  • Portal Vein (pathology)
  • Rats
  • Rats, Inbred F344
  • Transfection
  • Vascular Neoplasms (genetics, metabolism, secondary)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: