[Usefulness of bone remodelling biochemical markers in the diagnosis and follow-up of Paget's bone disease, primary hyperparathyroidism, tumor hypercalcemia, and postmenopausal osteoporosis. II. Bone resorption markers].

Abstract

Rapid detection of the exact changes in bone remodelling is exceptionally important. In this paper, the latest bone remodelling biochemical markers are reviewed. Some of them have already been used for a long time, and their utility has been widely demonstrated. The newest ones, in experimental stage, can be used as a complement to the others. The bone remodelling markers reviewed are: 1) Alkaline phosphatase; 2) osteocalcin; 3) other noncollagen of bone matrix such as osteonectin, GLA-protein of the matrix, osteopontine and alpha 2-HS-glycoprotein; 4) Procollagenous and other collagenous peptides of the matrix (C terminal of type I procollagen and urinary elimination of non-dialysis hydroxyproline. Amongst the bone resorption markers studied are: 1) Calcium/creatinine urinary quotient; 2) Tartrate resistant acid phosphatase; 3) Urinary hydroxyproline; 4) Other substance derived from collagen disruption such as hydroxylysine glycoside, piridinolinic intermolecular bridges and the enzymatic activity of proline iminopeptidase. We endeavored to collect all the most important references on the matter, especially those relating to Paget's disease of the bone, primary hyperparathyroidism, tumoral hypercalcemia and postmenopausal osteoporosis.

• Authors: C de la Piedra Gordo, R Torres Jiménez
• Journal: Anales de medicina interna (Madrid, Spain : 1984) (An Med Interna) Vol. 7 Issue 10 Pg. 534-8 (Oct 1990) ISSN: 0212-7199 [Print] Spain
• Vernacular Title: Utilidad de los marcadores bioquímicos de remodelamiento óseo en el diagnóstico y seguimiento de la enfermedad ósea de Paget, hiperparatiroidismo primario, hipercalcemia tumoral y osteoporosis postmenopáusica. II. Marcadores de reabsorción ósea.
• PMID: 2104101 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Biomarkers
• Acid Phosphatase
• Hydroxyproline

Topics

• Acid Phosphatase (blood)
• Adult
• Biomarkers
• Bone Resorption
• Child
• Female
• Follow-Up Studies
• Humans
• Hydroxyproline (urine)
• Hypercalcemia (diagnosis, etiology, metabolism)
• Hyperparathyroidism (diagnosis, metabolism)
• Male
• Neoplasms (complications)
• Osteitis Deformans (diagnosis, metabolism)
• Osteoporosis, Postmenopausal (diagnosis, metabolism)