Abstract | OBJECTIVES: We sought to assess the association between inflammation in pericardial fat (PF) and coronary artery disease (CAD) by pathological examination and clinical evaluation with cardiac computed tomography (CT). BACKGROUND:
Inflammation of adipose tissue is involved in cardio-metabolic disorders and shows high density in CT. METHODS: RESULTS: Pericoronary PF had significantly more LCA-positive cells in CAD autopsy cases (n=21) than non-CAD cases (n=18) (44 ± 21 vs. 24 ± 22 cells/mm(2), p=0.006). The CT density of PF around culprit lesions was significantly higher than non-culprit lesions in patients with acute coronary syndromes (-72 ± 11 vs. -82 ± 14 HU, p=0.002), which may reflect PF inflammation. Among patients suspected of CAD, the pericardial CT density gradient (PDG; difference in CT density between pericoronary PF and PF apart from coronary arteries) was significantly greater in CAD patients ( n=30) than non-CAD patients (n=39) (22 ± 16 vs. 16 ± 10 HU, p=0.046). Multiple logistic regression analysis demonstrated that the PF inflammation index (PFI; PDG × PF volume, which could be the integrated index of inflammatory activity and abundance of PF) was significantly associated with the presence of CAD (odds ratio [95% confidence interval]; 1.234 [1.012-1.503] per 1000 HU cm(3), p=0.037) independent of other metabolic risk factors such as hypertension, dyslipidemia, and diabetes. CONCLUSIONS:
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Authors | Masaaki Konishi, Seigo Sugiyama, Yuichiro Sato, Shuichi Oshima, Koichi Sugamura, Toshimitsu Nozaki, Keisuke Ohba, Junichi Matsubara, Hitoshi Sumida, Yasuhiro Nagayoshi, Kenji Sakamoto, Daisuke Utsunomiya, Kazuo Awai, Hideaki Jinnouchi, Yasushi Matsuzawa, Yasuyuki Yamashita, Yujiro Asada, Kazuo Kimura, Satoshi Umemura, Hisao Ogawa |
Journal | Atherosclerosis
(Atherosclerosis)
Vol. 213
Issue 2
Pg. 649-55
(Dec 2010)
ISSN: 1879-1484 [Electronic] Ireland |
PMID | 21040916
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Leukocyte Common Antigens
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Topics |
- Adipose Tissue
(pathology)
- Aged
- Autopsy
- Coronary Artery Disease
(pathology)
- Coronary Disease
(pathology)
- Female
- Humans
- Leukocyte Common Antigens
(analysis)
- Male
- Middle Aged
- Pericarditis
(pathology)
- Pericardium
(pathology)
- Tomography, X-Ray Computed
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