Abstract |
Sixty consecutive patients with endoscopically proven duodenal ulcers were given colloidal bismuth subcitrate tablets either as 120 mg q.d.s. or 240 mg b.d., in a randomized single-blind study. The efficacy of each regimen was determined by endoscopic examination and antral biopsy at 4 weeks; if the ulcer remained unhealed, treatment was continued and endoscopy repeated at 8 weeks. The ulcer-healing efficacy of the two regimens was identical; however, in the four times daily group only 27% remained Campylobacter pylori positive after 8 weeks of treatment compared with 58% of the twice-daily group. Similarly, only 21% of twice daily patients were free of histological gastritis compared with 42% of the four times daily patients.
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Authors | J Coghlan, L Hutchinson, D Gilligan, D McKenna, C Keane, E Sweeney, C O'Morain |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 4
Issue 1
Pg. 49-54
(Feb 1990)
ISSN: 0269-2813 [Print] England |
PMID | 2104073
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Ulcer Agents
- Colloids
- Organometallic Compounds
- bismuth tripotassium dicitrate
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Topics |
- Anti-Ulcer Agents
(administration & dosage, therapeutic use)
- Colloids
- Duodenal Ulcer
(drug therapy, microbiology, pathology)
- Endoscopy, Gastrointestinal
- Gastritis
(drug therapy, pathology)
- Helicobacter pylori
(drug effects)
- Humans
- Organometallic Compounds
(administration & dosage, therapeutic use)
- Single-Blind Method
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