Abstract | BACKGROUND AND AIMS: METHODS: This clinical trial was conducted in 51 epileptic children aged 1 - 16 years with refractory seizures from Feb. 2004 to Oct. 2006. Outcome measures included seizure frequency and adverse reactions. Twenty-seven patients left the study for various reasons, leaving 24 who continued the Atkins diet for a minimum of three months. Carbohydrates were initially limited to 10 g/day and fats constituted 60% of the total energy requirement. All participants received vitamin and calcium supplementation. RESULTS: Following three months of treatment with the Atkins diet, 16 patients (67%) had >50% decrease in seizure frequency, and 6 (25%) had >90% improvement, of whom 5 were seizure-free. Mean seizure frequency after the first, second and third months of treatment were significantly lower than at baseline (P values <0.001, 0.001 and 0.002, respectively). CONCLUSION:
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Authors | Seyed Hassan Tonekaboni, Parvin Mostaghimi, Parvin Mirmiran, Ali Abbaskhanian, Fatemeh Abdollah Gorji, Mohammad Ghofrani, Fereidoun Azizi |
Journal | Archives of Iranian medicine
(Arch Iran Med)
Vol. 13
Issue 6
Pg. 492-7
(Nov 2010)
ISSN: 1735-3947 [Electronic] Iran |
PMID | 21039004
(Publication Type: Clinical Trial, Journal Article)
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Topics |
- Adolescent
- Child
- Child, Preschool
- Diet, Carbohydrate-Restricted
(adverse effects)
- Epilepsy
(diet therapy)
- Female
- Humans
- Infant
- Male
- Prospective Studies
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