[Protective effects and pathogenesis of complex salvin miltiorrhiza on acute mercury poisoning in rabbits].

Abstract

OBJECTIVE:

To study protective effect and pathogenesis of complex salvia miltiorrhiza (DanShen) on acute mercury poisoning in rabbits.

METHODS:

Models of acute mercury poisoning was made in rabbits. The effect of complex salvia miltiorrhiza on blood urea nitrogen (BUN), copper-protein (CP), lactate dehydrogenase (LDH), acid phosphatase (ACP) and the malondialdehyde (MDA) in plasma, superoxide dismutase (SOD) in erythrocyte and MDA, SOD in tissues homogenate were observed.

RESULTS:

The administration of complex salvia miltiorrhiza after mercury injection 0.5 h and 9.5 h, decreased BUN, CP, MDA, LDH and ACP, and prevented the reduction of SOD. Compared with mercury poisoning group, the difference was statistical significant (P < 0.05, P < 0.01).

CONCLUSION:

It is suggested that acute mercury poisoning may result in renal damage but also multiple organ tissues, and complex salvia miltiorrhiza possesses protective effect, through stabilized membranes.

• Authors: You-Ling Jing, Yan-Lei Wang, Dan-Dan Yin, Bo-Hai Cao, Wei Zhang, Fei Geng, Na Sun
• Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology (Zhongguo Ying Yong Sheng Li Xue Za Zhi) Vol. 26 Issue 3 Pg. 341-4 (Aug 2010) ISSN: 1000-6834 [Print] China
• PMID: 21038687 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Phenanthrolines
• dan-shen root extract

Topics

• Animals
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Female
• Male
• Mercury Poisoning (blood, drug therapy)
• Phenanthrolines (pharmacology, therapeutic use)
• Rabbits
• Salvia miltiorrhiza