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Intravitreal injection of bevacizumab induces inflammatory alterations in a uveitis experimental model.

AbstractPURPOSE:
Bevacizumab is currently used as an intravitreal agent in the treatment of inflammatory-associated eye diseases. The aim of the current study is to explore the effects of the intravitreal injection of bevacizumab on aqueous humour cytokines and chemokines in an experimental uveitis model.
METHODS:
Endotoxin-induced uveitis was induced in rats by footpad injections. Bevacizumab was administered by intravitreal injection (75 µg in 3-µL samples) and different chemokine and cytokine proteins were quantified in aqueous humor.
RESULTS:
Intravitreal administration of bevacizumab led to a several-fold increase of RANTES, MCP-1, and IFN-γ concentrations in aqueous humor of endotoxin-treated rats.
CONCLUSIONS:
Given the exacerbating effect of bevacizumab on inflammation agents and considering the increasing use of bevacizumab as an off-label intravitreal agent, care should be taken if an underlying inflammatory disease is present.
AuthorsSiv Johnsen-Soriano, Emma Arnal, María Sancho-Tello, María Muriach, Inmaculada Almansa, Francisco Bosch-Morell, Amparo Navea, Francisco J Romero
JournalEuropean journal of ophthalmology (Eur J Ophthalmol) 2011 Jul-Aug Vol. 21 Issue 4 Pg. 427-33 ISSN: 1724-6016 [Electronic] Italy
PMID21038308 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal, Humanized
  • Ccl2 protein, rat
  • Chemokine CCL2
  • Chemokine CCL5
  • Cytokines
  • Lipopolysaccharides
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Bevacizumab
  • Interferon-gamma
Topics
  • Angiogenesis Inhibitors (administration & dosage)
  • Animals
  • Antibodies, Monoclonal, Humanized (administration & dosage)
  • Aqueous Humor (metabolism)
  • Bevacizumab
  • Chemokine CCL2 (metabolism)
  • Chemokine CCL5 (metabolism)
  • Cytokines (metabolism)
  • Disease Models, Animal
  • Enzyme-Linked Immunosorbent Assay
  • Interferon-gamma (metabolism)
  • Intravitreal Injections
  • Lipopolysaccharides
  • Male
  • Rats
  • Rats, Inbred Lew
  • Uveitis (chemically induced, drug therapy, metabolism)
  • Vascular Endothelial Growth Factor A (antagonists & inhibitors)

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