A positive relationship between filamin and VEGF in patients with lung cancer.

Abstract

Induction of angiogenic responses by multiple factors, a crucial step in tumor growth and metastasis, is not completely understood. Recently, involvement of the cytoskeletal actin-binding proteins in angiogenesis has been suggested as a target for anti-neovascular cancer therapy in vitro. In this study, the expression of filamin A (FLNA) and vascular endothelial growth factor (VEGF) in paraffin-embedded tumor samples from patients with well-characterized lung tumors was immunohistochemically analyzed and compared with clinical variables and survival outcome. A positive expression of FLNA and VEGF was detected in the cytoplasm of tumor cells in 66 (48.2%) and 69 (50.4%) of the 137 patients with lung cancer, respectively (p<0.0001). A significant difference was observed between FLNA expression and VEGF expression. Although our findings do not suggest that the expression of FLNA alone plays an independent prognostic role, the angiogenesis pathway mediated by FLNA appears to be responsible for controlling the growth of lung tumors.

• Authors: Hidetaka Uramoto, Levent M Akyürek, Takeshi Hanagiri
• Journal: Anticancer research (Anticancer Res) Vol. 30 Issue 10 Pg. 3939-44 (Oct 2010) ISSN: 1791-7530 [Electronic] Greece
• PMID: 21036706 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contractile Proteins
• Filamins
• Microfilament Proteins
• TNFSF15 protein, human
• Tumor Necrosis Factor Ligand Superfamily Member 15

Topics

• Adult
• Aged
• Aged, 80 and over
• Cohort Studies
• Contractile Proteins (biosynthesis)
• Cytoplasm (metabolism)
• Female
• Filamins
• Humans
• Immunohistochemistry
• Lung Neoplasms (blood supply, metabolism, pathology)
• Male
• Microfilament Proteins (biosynthesis)
• Middle Aged
• Neovascularization, Pathologic (metabolism, pathology)
• Paraffin Embedding
• Retrospective Studies
• Tumor Necrosis Factor Ligand Superfamily Member 15 (biosynthesis)