The efficacy of radiotherapy in the treatment of orbital pseudotumor.

Abstract

PURPOSE:

To review institutional outcomes for patients treated with external-beam radiotherapy (EBRT) for orbital pseudotumor.

METHODS AND MATERIALS:

This is a single-institution retrospective review of 20 orbits in 16 patients diagnosed with orbital pseudotumor that received EBRT at the University of Oklahoma, Department of Radiation Oncology. Treated patients had a median follow-up of 16.5 months.

RESULTS:

Fifteen patients (93.7%) were initially treated with corticosteroids. Eight had recurrence after steroid cessation, six were unable to taper corticosteroids completely or partially, and one experienced progression of symptoms despite corticosteroid therapy. Fourteen patients (87.5%) initially responded to radiotherapy indicated by clinical improvement of preradiation symptoms and/or tapering of corticosteroid dose. Mean EBRT dose was 20 Gy (range, 14-30 Gy). Thirteen patients (81.2%) continued to improve after radiation therapy. Patient outcomes were complete cessation of corticosteroid therapy in nine patients (56.3%) and reduced corticosteroid dose in four patients (25%). Radiotherapy did not achieve long-term control for three patients (18.7%), who still required preradiation corticosteroid dosages. Three patients received retreatment(s) of four orbits, of which two patients achieved long-term symptom control without corticosteroid dependence. One patient received retreatment to an orbit three times, achieving long-term control without corticosteroid dependence. No significant late effects have been observed in retreated patients.

CONCLUSIONS:

Radiotherapy is an effective treatment for acute symptomatic improvement and long-term control of orbital pseudotumor. Orbital retreatment can be of clinical benefit, without apparent increase in morbidity, when initial irradiation fails to achieve complete response.

• Authors: Chance Matthiesen, Carl Bogardus Jr, J Spencer Thompson, Bradley Farris, Lloyd Hildebrand, Byron Wilkes, Elizabeth Syzek, Ozer Algan, Salahuddin Ahmad, Terence Herman
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 79 Issue 5 Pg. 1496-502 (Apr 01 2011) ISSN: 1879-355X [Electronic] United States
• PMID: 21035962 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Adrenal Cortex Hormones

Topics

• Adolescent
• Adrenal Cortex Hormones (therapeutic use)
• Adult
• Aged
• Aged, 80 and over
• Combined Modality Therapy (methods)
• Humans
• Male
• Middle Aged
• Orbital Pseudotumor (drug therapy, radiotherapy)
• Radiotherapy Dosage
• Radiotherapy, Conformal (methods)
• Retreatment
• Retrospective Studies
• Young Adult