Steve Woods's contribution to research on amylin's eating inhibitory effect.

Amylin is secreted by pancreatic beta-cells and seems to function as a physiological signal of satiation and possibly also as an adiposity signal. Amylin's satiating effect is mediated via a direct action at area postrema (AP) neurons. The central pathways mediating amylin's effects rely on connections from the AP to the nucleus of the solitary tract and lateral parabrachial nucleus. Amylin was shown to interact, probably at the brainstem, with other satiating signals, namely cholecystokinin, glucagon-like peptide 1 and peptide YY, and other adiposity signals, namely leptin and insulin. The interaction with leptin, which is thought to involve the hypothalamus, may have important implications for the development of new and improved hormonal anti-obesity treatments. Steve Woods has contributed to the recent literature on amylin's eating inhibitory effect by some frequently cited publications. Steve's work concentrated more on the central administration of amylin and on amylin's potential role as an adiposity signal. His work will be reviewed here and discussed in the context of other important findings on amylin's role in the control of energy homeostasis.
AuthorsThomas Alexander Lutz
JournalPhysiology & behavior (Physiol Behav) Vol. 103 Issue 1 Pg. 25-30 (Apr 18 2011) ISSN: 1873-507X [Electronic] United States
PMID21035478 (Publication Type: Biography, Historical Article, Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2010 Elsevier Inc. All rights reserved.
Chemical References
  • Appetite Depressants
  • Islet Amyloid Polypeptide
  • Adiposity (drug effects)
  • Animals
  • Appetite Depressants (history, pharmacology)
  • Biomedical Research (history)
  • Body Weight (drug effects)
  • Energy Metabolism (drug effects)
  • Feeding Behavior (drug effects)
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Islet Amyloid Polypeptide (history, pharmacology)
  • Neurons (drug effects)
  • Signal Transduction (drug effects)
  • Solitary Nucleus (cytology)

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