Abstract | BACKGROUND: Sophorolipids (SLs) obtained from yeast broth are mixtures of many sophorolipid molecules with different structures, and have attracted more attention since they were found to have good antimicrobial, anticancer, anti-inflammatory, and anti-HIV activities. We investigated the effects of sophorolipid molecules with different structures on human esophageal cancer cells in the present work. MATERIALS AND METHODS: Ten sophorolipid (SL) molecules were separated and purified from the sophorolipids mixture using preparative HPLC, and their structures were identified by MS analyses. The effects of sophorolipid molecules with different structures on two human esophageal cancer cell lines, KYSE 109 and KYSE 450, were investigated by MTT assay. RESULTS: CONCLUSIONS: In this study, the relationship of anticancer activities of natural sophorolipid molecules and the differences in their structures was revealed, which probably further reveals the mechanism of SL bioactivities and will be helpful in the modification of SL structures to obtain more novel SLs with excellent bioactivities.
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Authors | Lingjian Shao, Xin Song, Xiaojing Ma, Hui Li, Yinbo Qu |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 173
Issue 2
Pg. 286-91
(Apr 2012)
ISSN: 1095-8673 [Electronic] United States |
PMID | 21035135
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Carcinoma, Squamous Cell
(drug therapy)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Drug Screening Assays, Antitumor
- Esophageal Neoplasms
(drug therapy)
- Glycolipids
(chemistry, isolation & purification, pharmacology, therapeutic use)
- Humans
- Molecular Structure
- Saccharomycetales
(chemistry)
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