Immunodominant antigens of Streptococcus mutans in dental caries-resistant subjects.

Previously, we reported that dental caries-resistant subjects, who have significantly fewer Streptococcus mutans in whole saliva than caries-susceptible patients, have significantly higher levels of naturally occurring binding and neutralizing parotid salivary immunoglobulin A and serum immunoglobulin G antibodies to native S. mutans antigens than caries-susceptible patients. Recent animal studies indicated that the immunogenicity of swallowed S. mutans may be altered by either saliva-coating or stomach acid-denaturation. These results suggest a difference not only in the quantity of antibody to S. mutans, but also in the antigenic epitopes that caries-resistant subjects synthesize antibody to as compared with caries-susceptible patients. In the present report, sodium dodecyl sulfate-polyacrylamide gel electrophoresis/immunoblotting studies indicate that caries-resistant subjects produce salivary immunoglobulin A and serum immunoglobulin G antibodies to several different (molecular weight: 94, 80, 40, and 35 kilodaltons) as well as several similar (molecular weight: 67, 55, and 30 kilodaltons) S. mutans epitopes as compared to caries-susceptible patients. This provides additional confirmation for our previous binding and functional antibody studies, indicating that caries-resistant subjects synthesize antibodies of different specificities than caries-susceptible patients. This study supports the concept of immune regulation of dental caries by naturally occurring antibodies induced by swallowing S. mutans antigens in saliva.
AuthorsR L Gregory, L C Hobbs, J C Kindle, T VanTo, H S Malmstrom
JournalHuman antibodies and hybridomas (Hum Antibodies Hybridomas) Vol. 1 Issue 3 Pg. 132-6 ( 1990) ISSN: 0956-960X [Print] UNITED STATES
PMID2103356 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Immunodominant Epitopes
  • Immunoglobulin A, Secretory
  • Immunoglobulin G
  • Antibodies, Bacterial (immunology)
  • Antigens, Bacterial (immunology)
  • DMF Index
  • Dental Caries (blood, immunology)
  • Disease Susceptibility (immunology)
  • Humans
  • Immunodominant Epitopes (immunology)
  • Immunoglobulin A, Secretory (immunology)
  • Immunoglobulin G (immunology)
  • Saliva (microbiology)
  • Streptococcus mutans (immunology)

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