[Investigation of anti-hypoxic action of 3-hydroxypyridine derivatives in animals with some types of experimental pathology].

Abstract

Experiments with occlusion of the common carotid artery in mice demonstrated that, unlike mexidol and SK-170, single injection of new derivatives of 3-hydroxypyridine (3-HP) SK-100 and IBKhF-2, and semax have an anti-hypoxic action on the model of acute normobaric hypoxia with hypercapnia. In analogous experiments with rats the distinct anti-hypoxic action was produced by 4 new 3-HP derivatives (SK-100, SK-170, IBKhF-22 at the dose of 100 mg/kg and IBKhF-2 at the doses of 10 and 30 mg/kg--extension of life span by 25-39%), mexidol (100 mg/kg) and reference-class antihypoxant amtisol (30 mg/kg, life span expansion by 19 and 27%, respectively). A series of experiments with rats with acute pancreatitis, a distinct anti-hypoxic action was shown by SK-100, SK-170 at 100 mg/kg and IBKhF at 10 and 30 mg/kg (life span extension by 26-40%), mexidol (100 mg/kg) and amtisol (30 mg/kg) which extended life span by 17 and 22%, respectively. Therefore, SK-100 and IBKhF-2 are potent to prolong life span of equally mice and rats; SK-170 and mexidol were effective only in experiments with rats.

• Authors: V V Iasnetsov, Iu V Ivanov, S K Karsanova, N A Chel'naia, S Ia Skachilova, N V Savina, N A Solov'ev, T V Filipenko, V N Luk'ianov
• Journal: Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine (Aviakosm Ekolog Med) 2010 May-Jun Vol. 44 Issue 3 Pg. 57-60 ISSN: 0233-528X [Print] Russia (Federation)
• PMID: 21033401 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antioxidants
• Pyridines
• 3-hydroxypyridine

Topics

• Animals
• Antioxidants (pharmacokinetics)
• Disease Models, Animal
• Hypoxia (drug therapy, metabolism)
• Male
• Mice
• Oxidative Stress (drug effects)
• Pyridines (pharmacology)
• Rats