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Traditional medicine Taeeumjowitangkagambang exerts antiobesity and hypolipidemic effects via antioxidant enzyme enhancement.

Abstract
Taeeumjowitangkagambang (ETJKB) is a traditional Korean medicine that has been clinically used for obesity with little mechanistic understanding. The present study investigated antiobesity and hypolipidemic effects of ETJKB in high fat diet fed rats as well as a 3T3-L1 pre-adipocyte differentiation model. ETJKB significantly inhibited the lipidogenesis in 3T3-L1 adipocytes in a concentration-dependent manner as well as reduced the cellular adipokine leptin level. Daily oral gavage of ETJKB to rats fed a high fat diet significantly attenuated body weight gain and abdominal and epididymal fat weights. ETJKB treatment also reduced the levels of total cholesterol, low density lipoprotein (LDL) and triglyceride as well as increased high density lipoprotein (HDL) in serum compared with the untreated control. Similarly, the ETJKB treatment decreased the levels of total lipid, triglyceride and cholesterol in liver tissue in high fat diet fed rats. Interestingly, ETJKB significantly increased the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase in liver tissue, while decreasing the hydroxyl radical, thiobarbituric acid reactive substances (TBARS), carbonyl concentration. An improvement of antioxidant enzymes was associated with improved body weight control and healthier lipid profiles and therefore may play an important role in the antiobesity and hypolipidemic effects of ETJKB.
AuthorsCheol-Hwan Park, Soo-Jin Jeong, Hyo-Jeong Lee, Eun-Ok Lee, Hyunsu Bae, Min-Ho Lee, Sun-Hyung Kim, Hee-Jae Jung, Kyoo Seok Ahn, Sung-Hoon Kim
JournalPhytotherapy research : PTR (Phytother Res) Vol. 24 Issue 11 Pg. 1700-9 (Nov 2010) ISSN: 1099-1573 [Electronic] England
PMID21031632 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2010 John Wiley & Sons, Ltd.
Chemical References
  • Anti-Obesity Agents
  • Antioxidants
  • Hypolipidemic Agents
  • Leptin
  • Lipoproteins, LDL
  • Plant Extracts
  • Thiobarbituric Acid Reactive Substances
  • Triglycerides
  • Cholesterol
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
Topics
  • 3T3-L1 Cells
  • Animals
  • Anti-Obesity Agents (pharmacology)
  • Antioxidants (metabolism)
  • Body Weight (drug effects)
  • Catalase (metabolism)
  • Cholesterol (blood)
  • Glutathione Peroxidase (metabolism)
  • Hypolipidemic Agents (pharmacology)
  • Leptin (analysis)
  • Lipid Peroxidation
  • Lipoproteins, LDL (blood)
  • Liver (drug effects)
  • Male
  • Medicine, Korean Traditional
  • Mice
  • Plant Extracts (pharmacology)
  • Rats
  • Rats, Sprague-Dawley
  • Superoxide Dismutase (metabolism)
  • Thiobarbituric Acid Reactive Substances (analysis)
  • Triglycerides (blood)

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