Analysis, identification and determination of urinary modified nucleosides of cancer and AIDS patients.

Abstract

Modified nucleoside levels in urine samples collected before and after surgery from seven patients with malignant gastrointestinal cancer were examined by the reversed-phase HPLC method. Those of an AIDS patient, a breast cancer patient, and pooled normal urines were also compared. To monitor the effects of therapy on cancer patients, the levels of modified nucleosides, especially t6A and MTA, were found to be fairly effective. In an AIDS patient, the levels of most of the nucleosides exhibited remarkable increases compared to normal urine.

• Authors: K Nakano, T Yasaka, T Nakao, K H Schram, W M Hammargren
• Journal: Nucleic acids symposium series (Nucleic Acids Symp Ser) Issue 22 Pg. 31-2 ( 1990) ISSN: 0261-3166 [Print] England
• PMID: 2101906 (Publication Type: Journal Article)

Chemical References

• Nucleosides

Topics

• Acquired Immunodeficiency Syndrome (urine)
• Breast Neoplasms (urine)
• Chromatography, High Pressure Liquid
• Gastrointestinal Neoplasms (surgery, urine)
• Humans
• Nucleosides (urine)