[Contraceptives and ischemic cardiopathy].

Abstract

The incidence of myocardial infarction is higher in women that use oral contraceptives. The most important pathophysiologic mechanisms are: a) modification of coronary risk factors: the pill produces an elevation of both serum cholesterol and trygliceride levels, increase of blood pressure and decompensation of diabetes mellitus; b) blood coagulation disorders: oral contraceptives increase platelet aggregation and fibrinogen blood levels, therefore they have a considerable thrombogenic capacity. At this moment there are several update publications concerning this matter; however most of the mechanisms involved in the increase of coronary heart disease in this specific group still remain unclear.

• Authors: I García-Bolao, E Alegría, I Iglesias, S Velasco, P Alzamora, M L Fidalgo
• Journal: Revista de medicina de la Universidad de Navarra (Rev Med Univ Navarra) 1990 Jul-Sep Vol. 34 Issue 3 Pg. 144-50 ISSN: 0556-6177 [Print] Spain
• Vernacular Title: Contraceptivos y cardiopatía isquémica.
• PMID: 2101493 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Contraceptives, Oral, Hormonal
• Estrogens
• Progestins
• Cholesterol

Topics

• Arteriosclerosis (chemically induced)
• Blood Coagulation Disorders (chemically induced)
• Cholesterol (metabolism)
• Contraceptives, Oral, Hormonal (adverse effects)
• Coronary Disease (chemically induced)
• Diabetes Mellitus (chemically induced)
• Estrogens (adverse effects)
• Female
• Humans
• Hypertension (chemically induced)
• Progestins (adverse effects)
• Structure-Activity Relationship