[Oral contraceptive and hepatic effects].

Abstract

The general use of synthetic estrogens like DC pointed out that near many skilled collateral effects, some others that are showing with a decrease of bile excretion (cholestasis), reversible with their administration interruption; with hepatic cells adenoma that are potentially premalignant and can transform into hepatocellular carcinoma; with vascular complications such as (most frequently in carcinomatousis) "hepatic peliosis" and "thrombosis" of suprahepatic veins (Budd-Chiari's syndrome). There is no overall increase in the incidence of gallbladder disease (cholelithiasis and cholecystitis).

• Authors: G Tarantino, L Morelli, C Califano
• Journal: Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques (Riv Eur Sci Med Farmacol) Vol. 12 Issue 3 Pg. 165-8 (Jun 1990) ISSN: 0392-291X [Print] Italy
• Vernacular Title: Contraccettivi orali e danno epatico.
• PMID: 2101166 (Publication Type: Journal Article, Review)

Chemical References

• Contraceptives, Oral, Hormonal

Topics

• Chemical and Drug Induced Liver Injury (etiology)
• Cholestasis (chemically induced, physiopathology)
• Contraceptives, Oral, Hormonal (adverse effects)
• Female
• Humans
• Liver Neoplasms (chemically induced)