[Tear enzymes in the treatment of an experimental alkaline corneal burn with gordox].

Abstract

The study of the influence of hordox, in treatment of experimental alkaline burn of the cornea, on the activity of trypsin-like proteases, elastases, callicreine, beta-N-acetylglucosaminidase and beta-glucuronidase in a tear fluid has shown that activity of these enzymes in a tear after burn remarkably increases, especially within first 24 hours and at the end of the second week after burn. In treatment by hordox, the activity of all enzymes in the tear, except elastase, reduces as compared with untreated animals, that speaks about antiinflammatory action of the preparation. On the basis of the data obtained it is suggested that investigation of hydrolytic enzymes in a tear can serve as a criterion for aimed correction of proteolysis in inflammatory processes in the cornea.

• Authors: N B Chesnokova, N E Sosulina, T P Kuznetsova
• Journal: Oftalmologicheskii zhurnal (Oftalmol Zh) Issue 6 Pg. 351-4 ( 1990) ISSN: 0030-0675 [Print] Ukraine
• Vernacular Title: Fermenty slezy pri lechenii éksperimental'nogo shchelochnogo ozhoga rogovitsy gordoksom.
• PMID: 2100779 (Publication Type: English Abstract, Journal Article)

Chemical References

• Trypsin Inhibitors
• gordox
• Sodium Hydroxide
• Aprotinin
• Glycoside Hydrolases
• Endopeptidases

Topics

• Animals
• Aprotinin
• Burns, Chemical (drug therapy, enzymology)
• Cornea (drug effects)
• Corneal Injuries
• Drug Evaluation, Preclinical
• Endopeptidases (drug effects, metabolism)
• Eye Burns (chemically induced, drug therapy, enzymology)
• Glycoside Hydrolases (drug effects, metabolism)
• Rabbits
• Sodium Hydroxide
• Tears (drug effects, enzymology)
• Time Factors
• Trypsin Inhibitors (therapeutic use)