Long-lasting effects on rheology and clearance of bronchial mucus after short-term administration of high doses of carbocysteine-lysine to patients with chronic bronchitis.

Abstract

The rheological behavior and clearance of bronchial mucus samples collected by protected expectoration from 24 out-patients with simple chronic bronchitis were investigated before, at the end of a short period of treatment (4 days) with a single oral dose of 2.7 g (sachet) of carbocysteine-lysine (evening meal), and on the 4th and 8th days after the end of treatment versus placebo. In the group treated with carbocysteine-lysine, there were significant reductions in viscosity (-67, -48, -62%) and increases in mucociliary transport (+41, +31, +34%) at the three times mentioned. The most striking finding was that the improvements were still present 8 days after cessation of treatment. The elasticity parameter was not affected in any statistically significant way (-10, -24, +65%). These findings suggest the presence of some type of 'post-mucoactive' effect.

• Authors: P C Braga, L Allegra, C Rampoldi, A Ornaghi, G Beghi
• Journal: Respiration; international review of thoracic diseases (Respiration) Vol. 57 Issue 6 Pg. 353-8 ( 1990) ISSN: 0025-7931 [Print] Switzerland
• PMID: 2099568 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Carbocysteine

Topics

• Adult
• Aged
• Bronchitis (metabolism)
• Carbocysteine (pharmacokinetics)
• Chronic Disease
• Female
• Humans
• Male
• Middle Aged
• Mucociliary Clearance
• Mucus (metabolism)
• Random Allocation
• Rheology
• Viscosity