| Abstract | Endemic goitre is accompanied by a spectrum of iodine deficiency disorders (IDD). From work undertaken by CEMUBAC in Ubangui Zaïre, the role of thiocyanate overload is recalled while this work demonstrates for the first time in man an action of selenium supplementation (and thus deficiency) on thyroid function in iodine deficient areas. The extreme severity of the selenium deficiency may intervene either on the central and/or peripheral deiodination of thyroxine, or on the synthesis of the thyroid hormones. Together with thiocyanate overload, selenium deficiency may be responsible of the high frequency of myxedematous cretins in Zaïre. |
| Authors | C H Thilly, B Contempre, J B Vanderpas
(Affiliation: Ecole de Santé publique, Université libre de Bruxelles.)
|
| Journal | Bulletin et mémoires de l'Académie royale de médecine de Belgique
(Bull Mem Acad R Med Belg)
Vol. 145
Issue 11
Pg. 440-8; discussion 448-50
( 1990)
ISSN: 0377-8231 BELGIUM |
| Vernacular Title | Surcharge en thiocyanate et carence en sélénium: des cofacteurs dans l'étiologie du goitre et du crétinisme endémiques au Nord-Zaïre. |
| PMID | 2099229
(Publication Type: English Abstract, Journal Article)
|
| Chemical References |
- Thiocyanates
- Iodine
- Selenium
|
| Topics |
- Adolescent
- Child
- Child, Preschool
- Congenital Hypothyroidism
(etiology, metabolism)
- Democratic Republic of the Congo
- Diet
- Goiter, Endemic
(etiology, metabolism)
- Humans
- Infant
- Iodine
(deficiency, metabolism)
- Selenium
(deficiency)
- Thiocyanates
(metabolism)
|
