Electrophysiological changes induced by paradoxical sleep deprivation and lithium chloride poisoning in rats.

In an attempt to analyze the disruption of conditioned taste aversion (CTA) caused by pre-acquisition paradoxical sleep deprivation (PSD), the effect of poisoning (0.15 M LiCl, 4% body weight) on the sleep--wakefulness pattern was studied in 12 rats with chronically implanted electrodes. The polygraphic recording showed that poisoning reduced the total sleep time in the subsequent 3 h from 57 to 42% and REM sleep from 6 to 2%. The lithium chloride effect was still more pronounced after 24-h REM sleep deprivation: the total sleep time decreased from 67 to 46% and REM sleep from 13 to 2%. The change of sleep--wakefulness pattern, most pronounced during the first hour of poisoning, gradually returned to normal but REM sleep was significantly reduced even 3 h after poisoning. It is concluded that 24-h PSD does not alleviate the subsequent poisoning. On the other hand, the lithium chloride induced reduction of post-acquisition REM sleep many enhance the learning impairment caused by pre-acquisition PSD.
AuthorsH Venkatakrishna-Bhatt, J Bures
JournalBrain research (Brain Res) Vol. 152 Issue 1 Pg. 97-103 (Aug 18 1978) ISSN: 0006-8993 [Print] NETHERLANDS
PMID209871 (Publication Type: Journal Article)
Chemical References
  • Lithium
  • Activity Cycles (drug effects)
  • Animals
  • Arousal (drug effects)
  • Avoidance Learning (drug effects)
  • Cerebral Cortex (physiology)
  • Electroencephalography
  • Electromyography
  • Hippocampus (physiology)
  • Lithium (poisoning)
  • Male
  • Rats
  • Sleep Deprivation
  • Sleep, REM (drug effects)
  • Taste (drug effects)

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