Abstract |
In an attempt to analyze the disruption of conditioned taste aversion (CTA) caused by pre-acquisition paradoxical sleep deprivation (PSD), the effect of poisoning (0.15 M LiCl, 4% body weight) on the sleep--wakefulness pattern was studied in 12 rats with chronically implanted electrodes. The polygraphic recording showed that poisoning reduced the total sleep time in the subsequent 3 h from 57 to 42% and REM sleep from 6 to 2%. The lithium chloride effect was still more pronounced after 24-h REM sleep deprivation: the total sleep time decreased from 67 to 46% and REM sleep from 13 to 2%. The change of sleep--wakefulness pattern, most pronounced during the first hour of poisoning, gradually returned to normal but REM sleep was significantly reduced even 3 h after poisoning. It is concluded that 24-h PSD does not alleviate the subsequent poisoning. On the other hand, the lithium chloride induced reduction of post-acquisition REM sleep many enhance the learning impairment caused by pre-acquisition PSD.
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Authors | H Venkatakrishna-Bhatt, J Bures |
Journal | Brain research
(Brain Res)
Vol. 152
Issue 1
Pg. 97-103
(Aug 18 1978)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 209871
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Activity Cycles
(drug effects)
- Animals
- Arousal
(drug effects)
- Avoidance Learning
(drug effects)
- Cerebral Cortex
(physiology)
- Electroencephalography
- Electromyography
- Hippocampus
(physiology)
- Lithium
(poisoning)
- Male
- Rats
- Sleep Deprivation
- Sleep, REM
(drug effects)
- Taste
(drug effects)
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