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[The clinical characteristics and treatment of community outbreaks of the new influenza A (H1N1) infection].

AbstractOBJECTIVE:
To describe the clinical characteristics of 3 community outbreaks of the novel influenza A (H1N1), and to compare the treatment effects of the traditional Chinese medicine with or without Oseltamivir.
METHOD:
The clinical records of 234 patients in 3 community outbreaks of the novel influenza A (H1N1) infection in June (n = 56), August (n = 96) and October (n = 82) of 2009 were analyzed, and the treatment effects of the traditional Chinese medicine with or without Oseltamivir were evaluated.
RESULTS:
The baseline characteristics, including age, temperature, indices of blood tests, hepatic and renal functions were distributed evenly between the 2 treatment groups. The overall analysis suggested that there was no significant difference between the 2 treatment groups in the duration of clinical symptoms (P > 0.05), the duration of fever (P > 0.05), and the hospitalization days (P > 0.05). However, an analysis stratified by the temperature (≥ 39°C or < 39°C) suggested that patients treated by the traditional Chinese medicine with Oseltamivir tended to suffer a shorter duration of fever [40.5 (37.3, 42.0) vs 22.0 (10.5, 30.8) hr, P < 0.01) ] in the higher temperature group.
CONCLUSIONS:
The traditional Chinese medicine was equivalent to oseltamivir in treating patients with the novel influenza A (H1N1) infection with lower temperature (< 39°C). Oseltamivir was effective in shortening the duration of fever in patients with temperature higher than 39°C.
AuthorsPing Wang, Min-li Zhu, Hai-jing Song, Qing Xiao, Xin-chun Kong, Wen-hong Peng, Shi-ling Xing, Ai-min Guo
JournalZhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases (Zhonghua Jie He He Hu Xi Za Zhi) Vol. 33 Issue 6 Pg. 419-21 (Jun 2010) ISSN: 1001-0939 [Print] China
PMID20979812 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Antiviral Agents
  • Drugs, Chinese Herbal
  • Oseltamivir
Topics
  • Adolescent
  • Adult
  • Antiviral Agents (therapeutic use)
  • Community-Acquired Infections (drug therapy, epidemiology, virology)
  • Drugs, Chinese Herbal (therapeutic use)
  • Female
  • Humans
  • Influenza A Virus, H1N1 Subtype
  • Influenza, Human (drug therapy, epidemiology, virology)
  • Male
  • Medicine, Chinese Traditional
  • Oseltamivir (therapeutic use)
  • Phytotherapy
  • Treatment Outcome
  • Young Adult

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