Abstract | BACKGROUND: OBJECTIVE: To compare the effectiveness of Aspirin vs Warfarin in TE prevention in patients with AF and RMVD. METHODS: A total of 229 patients (pts) with AF and RMVD were followed in a prospective and randomized study. The first group consisted of 110 pts receiving Aspirin - 200 mg/day (Group Aspirin - GA) and the second group consisted of 119 pts receiving Warfarin at individually-adjusted doses (Group Warfarin - GW). RESULTS: There were 15 embolic events in GA and 24 in GW (p = 0.187), of which 21 presented INR < 2.0. Thus, after excluding patients with inadequate INR, there was a higher number of embolic events in GA than in GW (15 vs 3) (p < 0.0061). The GW showed lower treatment adherence (p = 0.001). Neither group presented episodes of major bleeding. Small bleeding episodes were more frequent in the GW (p < 0.01). Increased serum levels of cholesterol and triglycerides constituted a risk factor for a higher number of thromboembolic events in the studied population, with no difference between the groups. CONCLUSION:
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Authors | Paulo de Lara Lavitola, Roney Orismar Sampaio, Walter Amorim de Oliveira, Berta Napchan Bôer, Flavio Tarasoutchi, Guilherme Sobreira Spina, Max Grinberg |
Journal | Arquivos brasileiros de cardiologia
(Arq Bras Cardiol)
Vol. 95
Issue 6
Pg. 749-55
(Dec 2010)
ISSN: 1678-4170 [Electronic] Brazil |
PMID | 20976374
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anticoagulants
- Warfarin
- Aspirin
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Topics |
- Aged
- Anticoagulants
(therapeutic use)
- Aspirin
(therapeutic use)
- Atrial Fibrillation
(metabolism)
- Bioprosthesis
- Heart Valve Prosthesis
- Hemorrhage
(epidemiology)
- Humans
- Male
- Medication Adherence
(statistics & numerical data)
- Mitral Valve Insufficiency
(metabolism, therapy)
- Prospective Studies
- Risk Factors
- Thromboembolism
(epidemiology, etiology, prevention & control)
- Warfarin
(therapeutic use)
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