Beneficial effects of chelidonic acid on a model of allergic rhinitis.

Abstract	Chelidonic acid (CA) is known as an inhibitor of the rat brain glutamate decarboxylase. However, the pharmacological effects of CA in allergic reactions have not yet been defined. Here, we show the effects and the mechanism of CA in the ovalbumin (OVA)-sensitized allergic rhinitis (AR) model. CA significantly decreased the number of nasal/ear rubs and increment of IgE levels in the AR mice. The level of interferon-γ was enhanced while the level of IL-4 was reduced on the spleen tissue of the CA-administered AR mice. Expressions of IL-1β and cyclooxygenase-2 were inhibited by CA administration in the nasal mucosa tissues. Infiltration of eosinophils and mast cells was decreased in the CA-administered AR mice. Furthermore, CA decreased the caspase-1 activity in the same nasal mucosa tissue and human mast cell line, HMC-1. Our results indicate that CA may attenuate allergic reaction by inhibition of caspase-1 activity.
Authors	Hyun-A Oh, Hyung-Min Kim, Hyun-Ja Jeong
Journal	International immunopharmacology (Int Immunopharmacol) Vol. 11 Issue 1 Pg. 39-45 (Jan 2011) ISSN: 1878-1705 [Electronic] Netherlands
PMID	20974310 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright Â© 2010 Elsevier B.V. All rights reserved.
Chemical References	Anti-Allergic Agents Interleukin-1beta Pyrans Interleukin-4 Immunoglobulin E Ovalbumin Ptgs2 protein, mouse Cyclooxygenase 2 Caspase 1 chelidonic acid
Topics	Animals Anti-Allergic Agents (administration & dosage, therapeutic use) Caspase 1 (metabolism) Cyclooxygenase 2 (biosynthesis) Disease Models, Animal Enzyme-Linked Immunosorbent Assay Eosinophils (drug effects, immunology) Female Histamine Release (drug effects) Immunoglobulin E (blood) Interleukin-1beta (biosynthesis, immunology) Interleukin-4 (immunology) Mast Cells (drug effects, immunology) Mice Mice, Inbred BALB C Nasal Mucosa (drug effects, enzymology, immunology) Ovalbumin (immunology) Pyrans (administration & dosage, therapeutic use) Rhinitis, Allergic, Perennial (drug therapy, enzymology, immunology) Spleen (drug effects, immunology)

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