Abstract | BACKGROUND: METHODS: We searched English and non-English publications in PubMed, Embase, Scopus, and the Cochrane Central Register of Controlled Trials from inception to January, 2010. Two evaluators independently selected and reviewed eligible studies. Sixteen randomized controlled trials, with 19 arms and 3,436 participants (1,848 assigned to a Mediterranean diet and 1,588 assigned to a control diet) were included. RESULTS: In a random-effects meta-analysis of all 19 arms, the Mediterranean diet group had a significant effect on weight [mean difference between Mediterranean diet and control diet, -1.75 kg; 95% confidence interval (CI), -2.86 to -0.64 kg] and body mass index (mean difference, -0.57 kg/m², -0.93 to -0.21 kg/m²). The effect of Mediterranean diet on body weight was greater in association with energy restriction (mean difference, -3.88 kg, -6.54 to -1.21 kg), increased physical activity (-4.01 kg, -5.79 to -2.23 kg), and follow up longer than 6 months (-2.69 kg, -3.99 to -1.38 kg). No study reported significant weight gain with a Mediterranean diet. CONCLUSIONS:
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Authors | Katherine Esposito, Christina-Maria Kastorini, Demosthenes B Panagiotakos, Dario Giugliano |
Journal | Metabolic syndrome and related disorders
(Metab Syndr Relat Disord)
Vol. 9
Issue 1
Pg. 1-12
(Feb 2011)
ISSN: 1557-8518 [Electronic] United States |
PMID | 20973675
(Publication Type: Journal Article, Meta-Analysis, Review)
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Topics |
- Adult
- Aged
- Algorithms
- Diet, Mediterranean
- Female
- Humans
- Male
- Middle Aged
- Obesity
(diet therapy)
- Randomized Controlled Trials as Topic
(statistics & numerical data)
- Sensitivity and Specificity
- Weight Loss
(physiology)
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