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An unusual mimicker of a sepsis outbreak: ergot intoxication.

Abstract
Methylergonovine (MEV) is a semi-synthetic ergot alkaloid used in the prevention and control of postpartum hemorrhage. This report describes 12 newborns born on the same day in a local country hospital in Turkey and developed sepsis-like symptoms and encephalopathy within the first 6 h of life due to accidental administration of MEV instead of vitamin K in the delivery room. The major features of MEV poisoning were lethargy (41.7%), seizure (75.0%), feeding intolerance (66.6%), hypoventilation (58.3%), irritability (25%), and peripheral circulatory abnormalities (58.3%). As a conclusion, clinical findings of ergot toxicity in newborns cannot be distinguished from infectious disease or neonatal encephalopathy.
AuthorsAhmet Yagmur Bas, Nihal Demirel, Ahmet Soysal, Kahraman Arslan, Ugur Dilmen
JournalEuropean journal of pediatrics (Eur J Pediatr) Vol. 170 Issue 5 Pg. 633-7 (May 2011) ISSN: 1432-1076 [Electronic] Germany
PMID20972685 (Publication Type: Journal Article)
Chemical References
  • Methylergonovine
Topics
  • Diagnosis, Differential
  • Ergotism (diagnosis)
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Medication Errors
  • Methylergonovine (poisoning, therapeutic use)
  • Sepsis (diagnosis)

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