Tenecteplase in the treatment of acute pulmonary thrombo-embolism.

Abstract

This is a retrospective study documenting the use of tenecteplase in 41 cases of suspected or confirmed pulmonary embolism receiving in-hospital tenecteplase as per weight-adjusted dosing in addition to standard heparin and oral anticoagulant therapy. The presenting symptoms of dyspnoea, chest pain, hemoptysis and syncope were found in 40 (97.56%), 19 (46.34%), 6 (14.63%) and 9 (21.95%) patients, respectively. There was one case of mortality who was a 26 yrs old female of postpartum pulmonary thrombo-embolism with severe hypotension, cyanosis, bilateral crepitations in lungs and pulmonary hypertension. In the 40 survived patients, there was alleviation of dyspnoea and hemoptysis in all patients. Significant reduction in tachycardia (P < 0.0001) and increase in the oxygen saturation (SaO₂) (P < 0.0001) were seen at discharge as compared to at the time of presentation. Eighteen patients had hypotension which recovered in all patients till the time of discharge (P < 0.0001). There was a significant reduction in right ventricular systolic pressure in all 18 patients who underwent 2-D echocardiography both before and after the tenecteplase therapy. Resolution of pulmonary embolism on CT pulmonary angiography was documented in only two patients. No bleeding events or any other adverse events were reported during this study. The present study suggests favourable efficacy of tenecteplase in patients with suspected or confirmed acute pulmonary embolism. Although no major adverse events were noted, a large prospective study on the use of tenecteplase in pulmonary embolism is suggested.

• Authors: J S Bhuvaneswaran, Rajendra Kumar Premchand, S S Iyengar, Rajeev Khare, C B Chabra, T N C Padmanabhan, S K Sharma, Alkesh Jain, S A Pandian, S Rajdev, N Modi, V Kumar
• Journal: Journal of thrombosis and thrombolysis (J Thromb Thrombolysis) Vol. 31 Issue 4 Pg. 445-8 (May 2011) ISSN: 1573-742X [Electronic] Netherlands
• PMID: 20972606 (Publication Type: Journal Article)

Chemical References

• Fibrinolytic Agents
• Tissue Plasminogen Activator
• Tenecteplase

Topics

• Acute Disease
• Adult
• Aged
• Blood Pressure (drug effects)
• Female
• Fibrinolytic Agents (administration & dosage)
• Humans
• Hypotension (blood, diagnostic imaging, drug therapy, physiopathology)
• Male
• Middle Aged
• Pulmonary Embolism (blood, diagnostic imaging, drug therapy, physiopathology)
• Radiography
• Retrospective Studies
• Tenecteplase
• Tissue Plasminogen Activator (administration & dosage)