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In vivo efficacy of doripenem (DRPM) against Pseudomonas aeruginosa in murine chronic respiratory tract infection model.

Abstract
Doripenem is a carbapenem antibiotic with broad-spectrum coverage of gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa, and is considered to be as effective as meropenem. The in vivo activity of doripenem was thus compared with that of meropenem in a chronic lower respiratory P. aeruginosa infection mouse model. The number of viable bacteria in the lungs of mice after treatment with doripenem, meropenem, and saline was 2.01 ± 0.69, 2.03 ± 0.48, and 3.90 ± 1.40 log₁₀ CFU/lung, respectively. The number of viable bacteria in the lungs of mice treated with doripenem and meropenem was significantly lower than that in lungs of controls. Histopathological examination of lung specimens from the control group revealed promotion of the inflammatory response in chronic bronchial infection. However, the groups treated with doripenem and meropenem showed weaker inflammatory responses. These results suggest that doripenem treatment is effective against chronic airway infection with P. aeruginosa.
AuthorsNobuko Araki, Katsunori Yanagihara, Yoshitomo Morinaga, Koichi Yamada, Yasuaki Yamada, Shigeru Kohno, Shimeru Kamihira
JournalJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 17 Issue 3 Pg. 318-21 (Jun 2011) ISSN: 1437-7780 [Electronic] Netherlands
PMID20972597 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Carbapenems
  • Thienamycins
  • Doripenem
  • Meropenem
Topics
  • Animals
  • Anti-Bacterial Agents (pharmacology)
  • Carbapenems (pharmacology)
  • Doripenem
  • Male
  • Meropenem
  • Mice
  • Pseudomonas Infections (drug therapy, microbiology, pathology)
  • Pseudomonas aeruginosa (drug effects)
  • Respiratory Tract Infections (drug therapy, microbiology, pathology)
  • Specific Pathogen-Free Organisms
  • Thienamycins (pharmacology)

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