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SK-PC-B70M alleviates neurologic symptoms in G93A-SOD1 amyotrophic lateral sclerosis mice.

Abstract
SK-PC-B70M, an oleanolic-glycoside saponins fraction extracted from the root of Pulsatilla koreana, carries active ingredient(s) that protects the cytotoxicity induced by Aβ(1-42) in SK-N-SH cells. It was recently demonstrated that SK-PC-B70M improved scopolamine-induced deficits of memory consolidation and spatial working memory in rats, and reduced Aβ levels and plaque deposition in the brains of the Tg2576 mouse model of Alzheimer disease. In the present study, we investigated whether SK-PC-B70M produces helpful effects on the pathology of the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis (ALS). Administration of SK-PC-B70M (100 or 400 mg/kg/day) from 8 weeks to 16 weeks of age attenuated neurological deficits of G93A-SOD1 mice in several motor-function-related behavioral tests. SK-PC-B70M treatment significantly suppressed the accumulation of the by-products of lipid peroxidation, malonedialdehyde (MDA) and 4-hydroxy-2-nonenal (HNE), in the spinal cord of G93A-SOD1 mice. Moreover, histologic analysis stained with cresyl violet or anti-choline acetyltransferase (ChAT) revealed that SK-PC-B70M suppressed neuronal loss in the ventral horn of the spinal cords of G93A-SOD1 mice. These results suggest that SK-PC-B70M affords a beneficial effect on neurologic deficits of G93A-SOD1 ALS mice.
AuthorsJi-Seon Seo, In-Sun Baek, Yea-Hyun Leem, Tae-Kyung Kim, Yearin Cho, Soo Min Lee, Yang Hae Park, Pyung-Lim Han
JournalBrain research (Brain Res) Vol. 1368 Pg. 299-307 (Jan 12 2011) ISSN: 1872-6240 [Electronic] Netherlands
PMID20971081 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2010 Elsevier B.V. All rights reserved.
Chemical References
  • Aldehydes
  • SK-PC-B70M
  • Saponins
  • Malondialdehyde
  • SOD1 G93A protein
  • Superoxide Dismutase
  • Choline O-Acetyltransferase
  • 4-hydroxy-2-nonenal
Topics
  • Aldehydes (metabolism)
  • Amyotrophic Lateral Sclerosis (drug therapy, pathology)
  • Animals
  • Anterior Horn Cells (drug effects, pathology)
  • Cell Survival (drug effects)
  • Choline O-Acetyltransferase (metabolism)
  • Disease Models, Animal
  • Lipid Peroxidation (drug effects)
  • Malondialdehyde (metabolism)
  • Mice
  • Mice, Transgenic
  • Motor Activity (drug effects)
  • Saponins (pharmacology)
  • Spinal Cord (drug effects, pathology, physiopathology)
  • Superoxide Dismutase (genetics)

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