Cholesterol-derived novel anti-apoptotic agents on the structural basis of ginsenoside Rk1.

Abstract

Design and synthesis of cholesterol-derived anti-apoptotic agents were described. The synthesized cholesterol analogs designed on the structural basis of ginsenoside Rk1 inhibited the undesirable apoptosis of human endothelial cells, which are induced by a vascular injury. In particular, analogue 1 possessing 4,6-di-O-acetyl-2,3-dideoxyhex-2-enopyran linked to hydroxyl group of cholesterol exhibited the most effective anti-apoptotic activities at both 5 and 10 μg/ml.

• Authors: Sujin Lee, Sony Maharjan, Kyeojin Kim, Nam-Jung Kim, Hyun-Jung Choi, Young-Guen Kwon, Young-Ger Suh
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 20 Issue 23 Pg. 7102-5 (Dec 01 2010) ISSN: 1464-3405 [Electronic] England
• PMID: 20971002 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Ginsenosides
• ginsenoside Rk1
• Cholesterol

Topics

• Apoptosis (drug effects)
• Blood Vessels (injuries, pathology)
• Cholesterol (analogs & derivatives, chemistry, pharmacology)
• Dose-Response Relationship, Drug
• Endothelial Cells (drug effects, pathology)
• Ginsenosides (chemistry)
• Humans
• Molecular Structure
• Structure-Activity Relationship