Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Studies of immunopathogenesis have shown a signification activation of both innate and adaptive immune responses with elevation of plasma or serum chemokines and cytokines. Markers of inflammation such as C-reactive protein, interferon-inducible protein 10 or interferon γ may be helpful as predictors of IRIS events. In addition, tuberculosis (TB)-associated IRIS is associated with a prominent Th1 response that can be heightened even prior to ART initiation in cases of unmasking TB, and may assist in early diagnosis. Large prospective studies are needed to elucidate the predictive and diagnostic value of IRIS biomarkers and advance them to the clinic. SUMMARY: Reversal of immunosuppression by ART leads to exaggerated pathogen-specific immune responses (known as IRIS) that appear to be primed prior to therapy. Inflammatory markers, chemokines and cytokines that signify innate and adaptive immune activation are biomarkers that could prove of clinical value after appropriate validation.
|
Authors | Irini Sereti, Alison J Rodger, Martyn A French |
Journal | Current opinion in HIV and AIDS
(Curr Opin HIV AIDS)
Vol. 5
Issue 6
Pg. 504-10
(Nov 2010)
ISSN: 1746-6318 [Electronic] United States |
PMID | 20966640
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Review)
|
Chemical References |
- Anti-Retroviral Agents
- Biomarkers
- C-Reactive Protein
|
Topics |
- Animals
- Anti-Retroviral Agents
(adverse effects, therapeutic use)
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- HIV Infections
(drug therapy, immunology)
- HIV-1
- Humans
- Immune Reconstitution Inflammatory Syndrome
(blood, immunology, microbiology, virology)
|