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Changing patterns of AIDS: impact on the indications and diagnostic yield of bone marrow biopsies.

Abstract
After the advent of HAART, the clinical course of HIV infection has dramatically improved. Therefore, it seems appropriate to reevaluate the performance of bone marrow biopsy (BMB) as a diagnostic tool. The aim of the present study was to compare the reasons for performing a BMB and its diagnostic yield in HIV-patients before and after HAART. A total of 165 BMB specimens obtained from HIV-infected patients receiving care at the Hospital of Universidade Federal do Rio de Janeiro in two different periods (1986-1994 and 1999-2004) were analysed. The main reason for BMB examination in the first period was fever (88%), which decreased in the second period (57%, p < 0.0001), when cytopenia (51%) was the leading reason for BMB, whereas in the first period it accounted for only 30% (p = 0.008). A definitive diagnosis (infection, granulomas or lymphomas) was obtained in 28% of patients in the first period and in 19% during the second period (p = 0.20). The diagnosis turned out as infections decreased from 16% in period 1 to 2% in period 2 (p = 0.003). Despite the the limitations in the evaluation of fever, the use of BMB must be considered on an individual basis, whenever less invasive alternatives have been exhausted, and should be complemented by a bone marrow aspiration for microbiological studies.
AuthorsJosé Carlos Morais, Marcel Machado, Irene Biasoli, Paulo Feijó Barroso, Cristiane Milito, Nelson Spector
JournalThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases (Braz J Infect Dis) 2010 Jul-Aug Vol. 14 Issue 4 Pg. 419-21 ISSN: 1678-4391 [Electronic] Brazil
PMID20963331 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-HIV Agents
Topics
  • Adolescent
  • Adult
  • Aged
  • Anti-HIV Agents (therapeutic use)
  • Antiretroviral Therapy, Highly Active
  • Biopsy
  • Bone Marrow (pathology)
  • Bone Marrow Examination (methods)
  • Child
  • Female
  • HIV Infections (complications, drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Young Adult

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