Abstract | BACKGROUND: We have previously examined isomaltitol in an in vitro static adhesion assay and were interested in investigating whether the potentially anti-inflammatory effects observed there could be relevant in vivo. The Sephadex-induced lung inflammation model was considered a suitablemodel due to the significant changes in global inflammatory endpoints seen upon provocation with Sephadex. METHODS: RESULTS: Differential counts showed that isomaltitol increased the neutrophil component while decreasing the eosinophilia, thus asserting a modulatory role on the usually eosinophil-dominated Sephadex-induced cell profile. Isomaltitol alone also increased edema and cysteinyl leukotrienes, and generally aggravated total inflammation in combination with Sephadex. The mechanisms were not investigated in this study, but effects could relate to a combination of isomaltitol's osmotic and structure-specific properties. CONCLUSION: Our results show that isomaltitol can modulate the inflammatory response induced by Sephadex instillation in addition to having proinflammatory effects on its own, and may therefore provide new insights into the mechanisms of this widely used animal model. Sugar alcohols similar to isomaltitol have already been used to aid mucus clearance in cystic fibrosis patients, and it is possible that isomaltitol could also be used for this purpose.
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Authors | Chamilly Evaldsson, Ingvar Rydén, Srinivas Uppugunduri |
Journal | International archives of allergy and immunology
(Int Arch Allergy Immunol)
Vol. 154
Issue 4
Pg. 286-94
( 2011)
ISSN: 1423-0097 [Electronic] Switzerland |
PMID | 20962533
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 S. Karger AG, Basel. |
Chemical References |
- Anti-Inflammatory Agents
- Dextrans
- Irritants
- Sugar Alcohols
- sephadex
- isomaltitol
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Topics |
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Bronchoalveolar Lavage Fluid
(chemistry, cytology, immunology)
- Dextrans
- Disease Models, Animal
- Eosinophilia
(chemically induced, etiology, immunology)
- Eosinophils
(drug effects)
- Irritants
- Male
- Neutrophils
(drug effects)
- Pneumonia
(chemically induced, immunology, pathology)
- Rats
- Rats, Sprague-Dawley
- Sugar Alcohols
(pharmacology)
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