Abstract | PURPOSE: The purpose of this study was to investigate the in vivo effects of a new smart polymer loaded with dexamethasone on inflamed rabbit eye. MATERIALS AND METHODS: RESULTS: Cross-linked copolymer of NIPAAM-VP-MAA was prepared by free radical copolymerization of the monomers in the presence of NIPAAM and TEGDMA as cross-linking agents and ammonium per sulfate (APS) as the initiator in high yields. The PSA data represented that the particles have mean sizes between 300-450 nm. Topical administration of prepared nanosuspensions clearly reduced uveitis symptoms, which were qualified with Hogan scoring. Statistical analysis represented that both of the nano formulations significantly reduced inflammation (p < 0.05) during 48 hr after LPS injection. CONCLUSION: Nanosuspension prepared with MBA showed rapid treatment in comparison with other nano formulations. The formulation also showed higher anti-inflammatory activity for a longer duration compared to aqueous suspension of the drug, which is due to small particle size and mucoadhesiveness of polymeric micelles.
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Authors | Farzaneh Rafie, Yousef Javadzadeh, Ali R Javadzadeh, Leila Alizadeh Ghavidel, Behzad Jafari, Mohammad Moogooee, Soodabeh Davaran |
Journal | Current eye research
(Curr Eye Res)
Vol. 35
Issue 12
Pg. 1081-9
(Dec 2010)
ISSN: 1460-2202 [Electronic] England |
PMID | 20961207
(Publication Type: Journal Article)
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Chemical References |
- Acrylamides
- Anti-Inflammatory Agents
- Cross-Linking Reagents
- Lipopolysaccharides
- Methacrylates
- Pyrrolidinones
- Dexamethasone
- N,N'-methylenebisacrylamide
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Topics |
- Acrylamides
(administration & dosage)
- Animals
- Anti-Inflammatory Agents
(therapeutic use)
- Chemical Phenomena
- Cross-Linking Reagents
(therapeutic use)
- Dexamethasone
(therapeutic use)
- Disease Models, Animal
- Drug Delivery Systems
- Eye Diseases
(chemically induced, drug therapy)
- Intravitreal Injections
- Lipopolysaccharides
- Methacrylates
(administration & dosage)
- Nanoparticles
(administration & dosage, chemistry)
- Pyrrolidinones
(administration & dosage)
- Rabbits
- Statistics, Nonparametric
- Time Factors
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