Evaluation of ovarian cancer biomarkers in subjects with benign asbestos-related pleural diseases.

Abstract

BACKGROUND:

Mesothelioma and ovarian cancer have been reported to have a similar pathogenesis, and for this reason it was hypothesized that there may be biomarkers in common and possibly associated with benign pleural diseases caused by asbestos exposure.

METHODS:

Serum biomarkers including insulin-like growth factor-II (IGF-II), leptin, prolactin and vascular endothelial growth factor (VEGF) were measured in an observational study of subjects with benign asbestos-related pleural diseases (BARPD) (n=24) and healthy subjects with an asbestos exposure history (n=12).

RESULTS:

Mean serum IGF-II and VEGF concentration in healthy subjects with a history of asbestos exposure were higher than those with BARPD. Mean serum concentrations of leptin and prolactin showed opposite trends when compared to IGF-II and VEGF concentrations among these groups.

CONCLUSIONS:

The results suggest that IGF-II and VEGF concentrations are lower in BARPD, similar to studies of ovarian cancer. This finding warrants further investigation with malignant asbestos-related diseases.

• Authors: Eun-Kee Park, Anthony R Johnson, Deborah H Yates, Paul S Thomas
• Journal: Clinical chemistry and laboratory medicine (Clin Chem Lab Med) Vol. 49 Issue 1 Pg. 147-50 (Jan 2011) ISSN: 1437-4331 [Electronic] Germany
• PMID: 20961188 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Leptin
• VEGFA protein, human
• Vascular Endothelial Growth Factor A
• Asbestos
• Insulin-Like Growth Factor II

Topics

• Aged
• Asbestos (poisoning)
• Biomarkers, Tumor (blood)
• Female
• Humans
• Insulin-Like Growth Factor II (metabolism)
• Leptin (blood)
• Male
• Middle Aged
• Ovarian Neoplasms (blood, pathology)
• Pleural Diseases (blood, etiology, pathology)
• Vascular Endothelial Growth Factor A (blood)