Evaluation of the effects of gallopamil in patients with effort angina by transesophageal atrial pacing two-dimensional echocardiography.

Abstract

Transesophageal atrial pacing (TAP) 2D echocardiography was performed after placebo (P) and gallopamil (G) (0.03 mg/kg iv) in 12 patients with stable, reproducible, effort angina. If compared to P study, during G the following changes were observed: 3 out of the 12 patients did not experience angina, time to ST-1mm increased from 5.3 +/- 1.3 to 6.6 +/- 1.6 min (p less than 0.05), wall motion score was improved both at 130 b/min (15.3 +/- 4.1 drug P, 17 +/- 4.8 drug G, p less than 0.01) and at 150 b/min (10.9 +/- 5.7 drug P, 12.8 +/- 6.3 drug G, p = 0.07). In conclusion, gallopamil has a beneficial effect on atrial pacing induced ischemia: it increases pacing time to ischemic threshold and reduces during ischemia the extent of dysfunctional myocardium.

• Authors: S Iliceto, C Caiati, G Piccinni, F Tota, G De Martino, V Marangelli, P Rizzon
• Journal: Cardiologia (Rome, Italy) (Cardiologia) Vol. 35 Issue 12 Pg. 1023-6 (Dec 1990) ISSN: 0393-1978 [Print] Italy
• PMID: 2095973 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Gallopamil

Topics

• Aged
• Angina Pectoris (drug therapy)
• Cardiac Pacing, Artificial
• Echocardiography
• Female
• Gallopamil (therapeutic use)
• Humans
• Male
• Middle Aged
• Posture