Desirable cell death during anticancer chemotherapy.

Abstract

The concept of immunogenic chemotherapy that has recently emerged relies upon the capacity of a cytotoxic compound to trigger a cell-death modality. This modality elicits cross-priming by dendritic cells of tumor antigen-specific T cells that will contribute to the tumoricidal activity of the compound and protect the host against relapse. In contrast, most anticancer drugs elicit nonimmunogenic apoptosis that is not accompanied with an immunizing property. This review will discuss some molecular and metabolic changes required at the level of the tumor that must engage key pathways at the level of the host for the induction of Tc1 polarized-protective T cell responses during chemotherapy. We will summarize the immune adjuvants that can boost the immunogenicity of cell death to augment the efficacy of chemotherapy.

• Authors: Clara Locher, Rosa Conforti, Laetitia Aymeric, Yuting Ma, Takahiro Yamazaki, Sylvie Rusakiewicz, Antoine Tesnière, François Ghiringhelli, Lionel Apetoh, Yannis Morel, Jean-Philippe Girard, Guido Kroemer, Laurence Zitvogel
• Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1209 Pg. 99-108 (Oct 2010) ISSN: 1749-6632 [Electronic] United States
• PMID: 20958322 (Publication Type: Journal Article, Review)
• Copyright: © 2010 New York Academy of Sciences.

Chemical References

• Antineoplastic Agents
• Cancer Vaccines

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Apoptosis (drug effects)
• Cancer Vaccines (administration & dosage)
• Combined Modality Therapy
• Humans
• Mice
• Neoplasms (drug therapy, immunology, pathology)