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Antibody dynamics after tick-borne encephalitis and measles-mumps-rubella vaccination in children post early thymectomy.

Abstract
Thymectomized patients (TP) showed a delayed humoral immune response to tick-borne-encephalitis-virus (TBEV) vaccination, which served as a neo-antigen. From the previously published cohort, the TBEV-specific IgG concentrations and avidities were analyzed in 17 TP compared to 30 non-thymectomized healthy controls (HC) 220 weeks after the first TBE vaccination to identify patients with waning antibodies. Only in HC, increase of avidity was significant between 8 and 220 weeks (p<0.001), whereas TP showed a lower avidity maturation at week 48 (p<0.05). Cytomegalovirus (CMV) seropositivity at vaccination did not influence the humoral immune response. The ability of TP to maintain measles, mumps and rubella (MMR)-specific antibodies at least 8 years post (MMR) vaccination was evaluated in the serum samples of TP, retrospectively. Although all TP had MMR vaccination at least 6 months after thymectomy, TP showed no significant difference regarding MMR-specific IgG concentrations or avidities compared to HC. Regarding TBE vaccination, the data confirmed the previous observation of a delayed primary immune response in TP to TBE vaccine and also revealed an altered memory priming by paucity of high-avidity antibodies.
AuthorsManuela Zlamy, Reinhard Würzner, Heidemarie Holzmann, Anita Brandstätter, Verena Jeller, Lothar Bernd Zimmerhackl, Martina Prelog
JournalVaccine (Vaccine) Vol. 28 Issue 51 Pg. 8053-60 (Nov 29 2010) ISSN: 1873-2518 [Electronic] Netherlands
PMID20955827 (Publication Type: Journal Article)
CopyrightCopyright © 2010 Elsevier Ltd. All rights reserved.
Chemical References
  • Antibodies, Viral
  • Immunoglobulin G
  • Measles-Mumps-Rubella Vaccine
  • Viral Vaccines
Topics
  • Adolescent
  • Antibodies, Viral (blood)
  • Antibody Affinity
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Immunocompromised Host
  • Immunoglobulin G (blood)
  • Infant
  • Male
  • Measles-Mumps-Rubella Vaccine (administration & dosage, immunology)
  • Thymectomy
  • Time Factors
  • Viral Vaccines (administration & dosage, immunology)

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