Abstract | BACKGROUND:
Stroke caused by brain ischemia is the third leading cause of adult disability. Active prevention and early treatment of stroke targeting the causes and risk factors may decrease its incidence, mortality and subsequent disability. Pien Tze Huang (PZH), a Chinese medicine formula, was found to have anti- edema, anti-inflammatory and anti-thrombotic effects that can prevent brain damage. This study aims to investigate the potential mechanisms of the preventive effects of Pien Tze Huang on brain damage caused by chronic ischemia and hypertensive stroke in rats. METHODS: The effects of Pien Tze Huang on brain protein expression in spontaneously hypertensive rat (SHR) and stroke prone SHR (SHRsp) were studied with 2-D gel electrophoresis and mass spectrometric analysis with a matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF)/TOF tandem mass spectrometer and on brain cell death with enzyme link immunosorbent assay (ELISA) and immunostaining. RESULTS: CONCLUSION:
Pien Tze Huang showed preventive effects on limiting the damage or injury caused by chronic ischemia and hypertensive stroke in rats. The effect of Pien Tze Huang was possibly related to prevention of cell death from apoptosis or ROS/oxidative damage in mitochondria.
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Authors | Lihong Zhang, Wai Ping Lam, Lanhai Lü, Chunmei Wang, Yeuk Wa Wong, Lok Hang Lam, Hong Chai Tang, Maria Sen Mun Wai, Mingwei Wang, Wing Hang Kwong, Sai Ming Ngai, Ying Tat Mak, David Tai Wai Yew |
Journal | Chinese medicine
(Chin Med)
Vol. 5
Pg. 35
(Oct 18 2010)
ISSN: 1749-8546 [Electronic] England |
PMID | 20955558
(Publication Type: Journal Article)
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